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Ann Endocrinol (Paris) ; 81(5): 507-510, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-778380

ABSTRACT

The World Health Organization (WHO) declared the COVID-19 epidemic to be a global pandemic in March 2020. COVID-19 is an infection caused by SARS-CoV-2, a coronavirus that utilizes the angiotensin-2 converting enzyme to penetrate thyroid and pituitary cells, and may result in a "cytokine storm". Based on the pathophysiological involvement of the pituitary-thyroid axis, the current review discusses the diagnosis of abnormal thyroid function test, and the management of patients presenting with thyrotoxicosis, thyroid-associated orbitopathy and hypothyroidism in the context of SARS-CoV-2 infection.


Subject(s)
Betacoronavirus , Coronavirus Infections/complications , Pandemics , Pneumonia, Viral/complications , Thyroid Diseases/etiology , Angiotensin-Converting Enzyme 2 , Apoptosis , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/physiopathology , Cytokine Release Syndrome/etiology , Cytokine Release Syndrome/physiopathology , Disease Susceptibility , Graves Ophthalmopathy/complications , Humans , Hydroxychloroquine/adverse effects , Hydroxychloroquine/therapeutic use , Hypothyroidism/blood , Hypothyroidism/etiology , Hypothyroidism/physiopathology , Interleukin-6/physiology , Peptidyl-Dipeptidase A/analysis , Pituitary Gland/physiopathology , Pneumonia, Viral/drug therapy , Pneumonia, Viral/physiopathology , Receptors, Virus/analysis , SARS-CoV-2 , Thyroid Diseases/blood , Thyroid Diseases/physiopathology , Thyroid Gland/chemistry , Thyroid Gland/pathology , Thyroid Gland/physiopathology , Thyroid Hormones/blood , Thyrotoxicosis/blood , Thyrotoxicosis/etiology , Thyrotoxicosis/physiopathology , Thyrotropin/blood , COVID-19 Drug Treatment
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